Development of an innovative corpus analysis platform designed to serve as a methodologically sound basis for (the) research on very large corpora in empirical linguistics.
Teacher competencies impact the quality of teaching in schools, and student outcomes. However, research on the development of these competencies within initial teacher preparation is rare. One reason for that is a lack of research instruments that allow measuring teacher competencies.
Against this background, the project KiL aims (1) at theoretically conceptualizing teacher competencies that develop during initial teacher education in the domains of science and mathematics, and (2) at the construction and validation of research instruments that allow measuring these competencies.
The financial crisis has shown that network structures in the financial sector were essential for the proliferation of shocks from the regional to the global level. The goal of this research project is to analyze the topology of these structures and to develop models that describe and explain the behavior of actors in the financial sector.
The research will increase our knowledge about the stability of the financial system. It will finally contribute to the development of a macro-prudential supervision and regulation of the financial sector by describing the risks from the inter-dependencies of actors.
Purpose of the project is the development of new biosensors for NMR diagnostics that pair the high sensitivity of hyperpolarized xenon with the high specificity of a functionalized targeting unit. We plan to advance the current status of xenon biosensors into applications of biomedical relevance and will develop novel probes for dual-mode (optical and NMR) detection. Addressing growth factors on malignant cells in cellular bioreactors and perfused organs will set the stage for the translation of this new technology into the early diagnosis of cancer.
Heritable epigenetic changes, or transgenerational effects, are the result of the fixation of epigenetic markers in the genome of gametes as a result of environmental impacts. Past research was focused on maternal epigenetics, neglecting the paternal influence on the next generation. To identify paternal effects we test in the wild guinea pig whether alterations of environmental conditions lead to changes in the methylation patterns in fathers. We also investigate whether those changes are also detectable in the male offspring, and thus paternally heritable. We further measure possible changes in embryonic gene expression as well as offspring development.
The project targets the integration of sub-mm-wave III-V components into a silicon BiCMOS process. Combining the two material systems offers unprecedented capabilities for circuit performance not possible with the separate technologies available so far. It promises a breakthrough in the field of Terahertz systems, enabling a variety of new applications from medicine and radio astronomy to security.
The aim of this project is the development of new preparation methods for miniaturized energy-storage systems including the synthesis of nano-structured composites and their integration in a fully operational device together with the determination of their behaviour and an interpretation of the performance parameters in terms of fundamental materials properties. This further understanding of materials interactions on the nano-scale will open new possibilities for autonomous microsystems with “on-board” energy supply and also improve nano-composite structures for bulk materials with better kinetics and higher capacities. The improvement of dedicated methods for the investigation of fundamental properties of functional materials on the nanometer scale will further strengthen the key competence of the IFW Dresden in this field.
The aim of the project is to develop a GaAs VGF-growth process in a heater magnet module (HMM) suitable for an industrial application. The influence of magnetic fields on the melt convection during the crystal growth was already demonstrated for germanium as a model substance. In this preliminary project, the first prototype of HMM was developed in IKZ. However, the industrial maturity of VGF-growth process was not reached. A technology to control the interface shape during the GaAs growth is to be developed that will provide crystals with improved quality. Thereby the dislocation density and crystal inhomogeinity have to be reduced.
Mechanical properties of surfaces and nanoscaled solids often prove to be different from macroscopic bulk behavior. The project objective is to determine the elastic properties of (nano-)structured and freestanding thin films using measuring techniques which are to be newly implemented and also a computational multiscale approach to explore the underlying physics in order to be transfered to industrial applications.
Period: 1. May 2011 – 30. November 2014
Contact: Professor Dr. Stefan G. Mayr und Professor Dr. Dr. Bernd Rauschenbach
Tel.: +49 341 2353368 / +49 341 2352308
E-Mail: stefan.mayr(at)iom-leipzig.de / bernd.rauschenbach(at)iom-leipzig.de
Project website (in German only)
Final report (PDF)
The project aims at exploring whether and how engineered polymer matrices can fortify the permeation of peptide-conjugated transcription factors across lipid bilayer membranes to enhance reprogramming of fibroblasts into induced pluripotent stem (iPS) cells by controlled, localized transcription factor delivery and provision of additional exogenous signals.
Tasks include expression and conjugation of transcription factors, customization of peptide-functionalized heparin-starPEG matrices, theoretical and experimental studies of protein transduction through membranes and generation and characterization of iPS cells.
Merging the power of transcription factors and extrinsic matrix signals in cell reprogramming, our approach can be expected to open exciting options for regenerative therapies.
It is the aim of the project to find out and to optimize efficient catalytic pathways for industrially relevant value-added products. This strategically oriented, interdisciplinary, and risky project comprises homogeneously and heterogeneously catalyzed reactions. Thereby a scientific approach is pursued which incorporates the development and testing of suitable catalysts, the elucidation of the catalyst mode of action, and the investigation of reaction kinetic and reaction engineering aspects.
Die Mechanismen des Ionentransports auf atomarer Skala sind von entscheidender Wichtigkeit sowohl für das Verständnis bestehender als auch für die Entwicklung zukünftiger Batterietechnologien. Wir untersuchen die Herstellung und Funktion von Batterie(teil)strukturen auf atomarer Skala mit einem integrierten Ansatz bestehend aus Molekularstrahlepitaxie, in-vivo-Strukturanalyse und theoretischer Modellierung. Dazu dient hochaufgelöste Röntgenbeugung am Synchtrotron während der Synthese und des Betriebs solcher Strukturen, kombiniert mit dichtefunktionaltheoriebasierter Analyse. Das Ziel ist die Erforschung ionentransportbasierter Mechanismen auf der Nanoskala für Anwendungen in Batterien und künftigen Bauelementen.
Period: 1. April 2011 – 31. March 2014
Contact: Dr. Oliver Bierwagen
Tel.: +49 30 20377491
Climate changes impact hydrophysical properties of aquatic ecosystems. This results in significant changes of biodiversity and ecosystem functions. Microorganisms, as most important drivers of biogeochemical processes, determine the function of lakes as source or sink of carbon. Because of their short generation times microorganisms respond very sensitively and fast to climate driven changes. A unique experimental facility consisting of 24 enclosures, each of 9 m diameter and reaching down into sediments at a depth of ca. 20 m, is used for simulations of climate driven patterns of stratification in the nutrient poor Lake Stechlin.
Studies on the changes in diversity of microbiota and in carbon metabolism are conducted to form a sound basis for the assessment of the impact of the forecasted climate change on aquatic ecosystems. This will allow the development of management strategies and countermeasures for stratified lakes.