The aim of this project is to clarify the role of adipokines and myokines in fat disposition in skeletal muscle and to study the crosstalk between adipocytes and myocytes. To this end, we will establish a sustainable network for muscle research in humans, animal models and farm animals. This will be accomplished by the exchange of methods, models, data and expertise of all partners. Although the partners ultimately have different goals (optimization of meat quality in farm animals and identification of novel therapeutic targets in humans) understanding the common basic principles is essential to accomplish these goals, making the project beneficial for all partners.
This project aims to clarify how synaptic signals are transduced from pre- and postsynaptic sites to the nucleus, how such signals induce long-lasting changes in gene expression and how this gene expression feeds back to synaptic function. We will investigate whether plasticity-related synaptic signals induce the nuclear import of synapto-nuclear protein messengers. Finally, we will follow up on the hypothesis that macromolecular complexes that contain transcription factors, co-activators and co-repressors, adaptors and scaffolders, kinases and phosphatases provide signalosome complexes for docking to nuclear target sites.
A significant portion of the biosphere exists in the frozen state but still harbors viable and physiologically active microorganisms. The project focuses on so-far unknown key physiological responses towards cryostress and their molecular basis. Selected bacteria, protozoa, fungi as well as animal and plant cell lines are investigated in a comparative approach. Main topics are changes in the permeability of the cell envelope, in energy metabolism and cell proliferation. Genes involved in the response to cryostress are analyzed by transcriptomics, proteomics and methylomics approaches. A final goal of the study is the analysis of novel cryoprotectants and their mode of action.
A network between the Leibniz Institutes IHP and FBH will be established in the project in the field of high-frequency electronics. The objective is a shared technology platform ("Science Fab") that allows external partners (universities, research institutes, industry) to access a cross-institutional production line for hetero-integrated circuits based on BiCMOS (IHP) and III-V bipolar (FBH) technology. The existing access to the IHP BiCMOS technology is expanded by hetero-integrated circuits based on InP on silicon BiCMOS in a Europe-wide unique way. The structure of the “Science Fab” guarantees sustainable cooperation between the institutes via substantial contributions of both partners.
Period: 1. January 2013 - 31. December 2015
Final report (PDF)
The aim of this project is to develop an all-semiconductor based, microintegrated laser system for the optical local oscillator of the world’s first portable Al+ optical clock currently being developed at PTB. Once operational, this clock will constitute one of the most accurate and stable clocks worldwide. The laser technology can later be transferred to optical clocks based on other atomic species. The project will make available an enabling technology for portable and space-based optical clocks. It will initiate a long-term cooperation between FBH and the National Metrology Institute PTB and will sustain a partnership between FBH and Humboldt University.
Period: 1. April 2013 - 31. December 2017
Final report (PDF)
The international and interdisciplinary project examines the process of computer-based 3D reconstruction of lost architecture and interior decoration. The project is funded by the Leibniz Association from 2013 to 2016. The preliminary results are based on the digital reconstruction of ruins of two baroque palaces: Schlodien, or Gładysze, now in Poland, and Friedrichstein, or Каменка, now in the Russian Federation. The results are concerned with indexing of sources, documentation, semantic modelling, and visualization of 3D data sets using WebGL-technology. The focus is on the development of a Cultural Heritage Markup Language (CHML), a human and machine-readable XML Schema for semantic annotation and integration of various meta and paradata, including the labelling of geometrical, material, and light characteristics in the source code.