Processes of residential mobility both within cities and between cities and the surrounding suburban municipalities are important drivers of urban development. Movement of people, flows, at the level of statistical districts are, however, difficult to analyse given their complexity and changes over time. Against this background, the interactive application hin&weg has been developed to map migrant flows between the statistical districts and municipalities of urban regions. The application provides the numerical means to describe and analyse population movements using existing data through visualisations and statistics. It has been developed in the context of research on reurbanisation and is currently in use by ten cities. hin&weg has also been the basis for interactive exhibits in two public exhibitions. The transfer project aims at turning the scientific application into a tool that fits the needs of the day-to-day work in city administrations, e.g. to improve the accuracy of population forecasts. The enhancements and refinements of hin&weg will be developed in close cooperation with future users employing a participative approach. The transfer project also establishes new (forms of) cooperations between research institutions and municipalities and puts in place an appropriate entity to manage and guide its future development and sustainable continuation through a subscription model.
Antibody-Drug conjugates (ADCs) are emerging biopharmaceutical agents for cancer therapy combining antibody-mediated tumor targeting with the cytotoxicity of small molecule drugs. The two ADCs that are currently on the market, Adcetris and Kadcyla, rely on the conjugation of maleimides to cysteines, a linkage that is instable in serum and prone to exchange with thiols of endogenous proteins leading to severe side-effects. Thus, novel conjugation technologies with increased stability are highly desired to widen the therapeutic window of ADCs. In this line, our lab recently developed a novel modular cysteine-bioconjugation technique named â€œP5-labelingâ€ using alkyne-phosphonamidates. In contrast to state-of-the-art maleimide-labeling, we observed a remarkable improvement in cell lysate stability and no thiol exchange with endogenous proteins. Furthermore, P5-labeling showed superior selectivity in the reaction with cysteine-residues compared to maleimides. First ADCs developed with our P5-labeling technique were evaluated in a breast cancer cell model showing highly efficient and cancer cell-specific cytotoxicity. Building upon this outstanding performance we propose for this SAW transfer project extensive in vitro and in vivo studies to evaluate the cytotoxicity, immunogenicity and the pharmacokinetic behavior of P5-labelled ADCs. Together with the evaluation of new toxophores with our collaboration partners we aim to introduce next generation ADCs with improved selectivity and potency for future clinical use.
The transfer from research into practice has been and still is described as being a major challenge in education. Studies and surveys point out demands that have already been ad-dressed by research and led to the development of teaching and learning materials, but which have not yet been implemented into practice. Frameworks and studies on implementation describe factors for successful implementation processes, such as continuous development, relevance for practice and an alignment of curriculum, instruction and assessment. Projects that enabled long-term developments in communities of practice have successfully led to changes and an application of research-based approaches, but even those had huge difficulties to be continued after the end of each project. Today, digital resources freely available on the internet represent one important source for teachers when planning and realizing teaching units. While availability and easy access are positive criteria with regard to distribution, quality control is often not provided. In addition, material without further support is rather integrated into existing routines instead of changing the latter in favor of results from research and theories. Open Educational Resources (OER) developed by research institutions provide freely available resources based on empirical foundations. However, up until now they do not yet systematically relate applicable material for science and maths teaching and learning to theoretical frameworks and empirical findings explicitly. Against this background, the goal of this transfer project is to provide an OER platform in the area of science and maths, to initiate its sustainable use and further development by virtual communities of practice and to evaluate the initiated processes with regard to different levels of implementation, such as teachers’ perceptions, adaptations of the material, or exemplary student results.