18.05.2020

Doctoral Researcher (f/m/d)

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. Talented and highly qualified candidates are invited to apply for a position in a newly established Junior Research Group of Dr. Mark S. Gresnigt as a

Doctoral Researcher (f/m/d)

in Adaptive Pathogenicity Strategies

for three years initially.

Research Areas: Microbiology, Mycology, Immunology

This project is part of a newly established Deutsche Forschungsgemeinschaft (DFG)-funded Emmy Noether research group that will investigate fungal adaptation to the inflammatory environment to better understand pathogenesis and treat fungal infections.

Project background: 

The immune system possesses elegant strategies to cope with potential harmful invading microorganisms. Nevertheless, pathogens themselves have evolved mechanisms to deal with the threats imposed by the immune system. Yeasts like Candida albicans are common commensals of the human microbiota, yet also major opportunistic fungal pathogens that frequently cause superficial and even fatal infections. The commensal co-existence with the human host allows co-evolution of fungal adaptation strategies in line with the threats imposed by the host, which are particularly represented by the immune system.

In this project, the successful applicant will investigate how C. albicans responds and adapts to immune mediators and how this influences commensalism and pathogenicity. The candidate will identify and characterize immune mediators that can induce fungal adaptations, and use in vitro model systems to investigate the impact on pathogenicity mechanisms and commensalism. The overarching goal is to elucidate the molecular mechanisms by which immune mediators induce fungal adaptations.

Candidate´s profile:

We expect a Master´s degree (or equivalent) in Life Sciences (e.g. Biology, Biochemistry, or Microbiology). Furthermore, the applicant should be able to perform team-oriented as well as independent work. Experimental background in one or more of the following subjects are beneficial: Immunology, Microbiology, Infection Biology. Practical experience in cell culture, microarrays, or fungal genetics is an advantage. Very good communication skills in English.

We offer:

The successful candidate will be hosted in the newly established Emmy Noether Junior Research Group of Dr. Mark S. Gresnigt. The Leibniz-HKI is embedded in the outstanding scientific environment of the Beutenberg Campus providing state-of-art research facilities and a highly integrative network of life science groups. We offer a multifaceted scientific project with excellent technical facilities, a place in a young, committed team, as well as strong scientific collaborations. The PhD candidate will participate in the structured program of the International Leibniz Research School and become an associated member of the Jena School of Microbial Communication.

Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer, the Leibniz-HKI is committed to increasing the percentage of female scientists and therefore especially encourages them to apply.

Further information:

Dr. Mark S. Gresnigt | +49 3641 532 1305 | career@leibniz-hki.de

Applications:

Complete applications in English, including a cover letter with a brief statement of research experiences, a CV with a complete list of publications, and the addresses of two possible referees, should be submitted by July 2, 2020 via the Leibniz-HKI online application system.

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