PhD student/doctoral student (f/m/d)
Leibniz Institute for Neurobiology (LIN), Magdeburg
The Leibniz Institute for Neurobiology is an internationally recognized neuroscientific research institute and dedicated to the research on learning and memory. Our research comprises all organizational levels of the brain – from molecular and cellular processes to complex neuronal networks and behavior. The Institute is a foundation under public law and committed to a comprehensive policy of Equal Opportunities in employment and research.
The Research Group Neuroplasticity at the Leibniz Institute for Neurobiology in Magdeburg (Germany) seeks 2 highly motivated
PhD students/doctoral students (f/m/d)
to join our team for a project dealing with synaptic autophagy funded by the DFG - FOR5228 Syntophagy “Membrane trafficking processes underlying presynaptic proteostasis”. This post is for a 3-year fixed-term period with a salary of TV-L E 13 (65%) starting October 1st 2021.
About the project: An intriguing possibility that hasn`t been investigated in detail is whether and how autophagy directly contributes to activity-dependent synaptic change. Unfortunately, it is currently unknown whether autophagy has a specific role in synaptic neurotransmission that goes beyond protein degradation and whether endosomal sorting processes and removal of membrane proteins at boutons actively contribute to synaptic plasticity. In support of this latter notion several recent studies suggest that different membrane sources and mechanisms might underlie phagophore formation in a stimulus-dependent manner. In this project we will try to understand whether the assembly of amphisomes at boutons is involved in presynaptic plasticity and long-range signaling. Autophagosomes fuse with late endosomes in order to undergo robust retrograde transport and we hypothesize that in the absence of autolysosome formation, the resulting amphisomes serve as signaling and sorting platforms while trafficking in a retrograde direction to the cell soma (see Andres-Alonso et al., Nat Comm., 2019). Our overarching hypothesis is that the enormous complexity of neuronal cytoarchitecture has led to ways of long-distance protein transport that combine degradative with signaling functions.
- completed university degree (master, diploma or similar qualification) in neuroscience, biology, biochemistry or other relevant discipline
- experience in cell biology, microscopy, imaging and/or biochemistry
- independent, self-reliant and dedicated style of work
We offer a stimulating environment and access to up-to-date methodology and a highly relevant collaborative research topic. A variety of techniques including primary neurons from transgenic animals growing in microfluidic devices, CRISPR-CAS9 gene editing in combination with imaging (spinning disk confocal, TIRF, STED) and in-vitro electrophysiology will be employed.
Your employment, salary and employee benefits comply with the collective pay agreement (German TV-L). Equal opportunities as well as compatibility of family and work are part of our HR policy. Severely disabled applicants with equivalent occupational aptitude will be considered preferentially.
Please submit your application in one PDF file including a detailed CV and names of two referees and brief statements of motivation and research interest via e-mail to Michael R. Kreutz (kreutz(at)lin-magdeburg.de) and Anna Karpova (Anna.Karpova(at)lin-magdeburg.de).
Applications will be considered until the positions are filled.
Please find our job post here.
For more information about our group, please visit https://www.lin-magdeburg.org/forschung/forschungseinheiten/research-group-neuroplasticity and http://www.kreutzlab.com/.