05.07.2019

Post-Doctoral Researcher (f/m/d)

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Jena

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (Leibniz-HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Department of Infection Biology invites talented and highly gifted candidates to apply for a

Post-Doctoral Researcher (f/m/d)

Complement Genetics

for two years initially.

Your profile:

  • Doctoral degree in biology, genetics or life sciences
  • Experience, knowledge and good experimental skills in molecular biology, genetics, biochemistry  are an advantage

We offer:

The successful candidates will investigate the field of Complement Genetics and Pathology of Renal Diseases. Main topics of the project are

  • Identification of Genetic Mutations of Complement Genes in Renal Diseases C3 Glomerulopathy  and aHUS
  • Next Generation Sequencing for Genetic Diagnostics
  • Functional characterization of FHR1, FHR2 and FHR5 proteins in complement contact and beyond

For further details please see literature below.

Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer the HKI is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

For further information

Please contact Prof. Dr. Peter Zipfel | +49 3641 532 1301 | career@leibniz-hki.de

Applications

Complete applications in English consisting of a letter of interest, CV, complete list of publications, brief statement of research experiences, a list of three potential references, and full academic record (copies of degree certificates) should be submitted by August 15, 2019 via the online application system.

Literature:

Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdaukas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C (2019) Factor H-related protein 1 (FHR1) senses necrotic cell stress and triggers sterile inflammation. Nature Communication, in press

Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF (2018) FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces. J Immunol 200(7), 2280-2290.

Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Büttner M, Goodship T, Hugo C, Skerka C, (2014) Complement factor H related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124, 145-155.

Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740.

www.leibniz-hki.de